Arsip Blog

Drugsafety – Antikonvulsan, Obat Tidur, Sedatif, dan Migren

DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI

Antikonvulsan, Obat Tidur, Sedatif, dan Migren

Nama Obat

R.Hamil

R.Menyusui

Sumatriptan

C L3
Chloral hydrate C L3
Methyprylon NR
Bromide D L5
Secobarbital D L3
Zolpidem B L3
Bishydroxycoumarin NR
Warfarin D L2
Carbamazepine C L2
Ethosuximide C L4
Magnesium sulfate B L1
Phenytoin D

L2

Valproic acid

D

L2

Lactation Risk Categories

  • L1 (safest)
  • L2 (safer)
  • L3 (moderately safe)
  • L4 (possibly hazardous)
  • L5 (contraindicated)

Pregnancy Risk Categories

  • A (controlled studies show no risk)
  • B (no evidence of risk in humans)
  • C (risk cannot be ruled out)
  • D (positive evidence of risk)
  • X (contraindicated in pregnancy)
  • NR: Not Reviewed. This drug has not yet been reviewed by Hale.

Drugsafety – Obat TBC dan Malaria

DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI

Obat TBC dan Malaria

Nama Obat

Risiko Kehamilan

Risiko Menyusui

Obat TB
Cycloserine

C

L3

Ethambutol

B

L2

Isoniazid

C

L3

Rifampin

C

L2

Obat malaria
Chloroquine

C

L3

Hydroxychloroquine

C

L2

Pyrimethamine

C

L4

Quinine

D

L2

** Per Medications’ and Mothers’ Milk by Thomas Hale, PhD (2004 edition).

 Lactation Risk Categories  Pregnancy Risk Categories
  • L1 (safest)
  • L2 (safer)
  • L3 (moderately safe)
  • L4 (possibly hazardous)
  • L5 (contraindicated)
  • A (controlled studies show no risk)
  • B (no evidence of risk in humans)
  • C (risk cannot be ruled out)
  • D (positive evidence of risk)
  • X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.

Drugsafety – Anti Hipertensi, Anti Aritmia, dan Diuretik

DAFTAR OBAT AMAN DAN BERBAHAYA UNTUK IBU HAMIL DAN MENYUSUI

Anti Hipertensi, Anti Aritmia, dan Diuretik

Nama Generik

Kategori Risiko Kehamilan**

RisikoMenyusui**

Acetazolamide

C

L2

Bendroflumethiazide

D

L4 (may inhibit lactation)

Chlorothiazide

D

L3

Chlorthalidone

D

L3

Hydrochlorothiazide (HCT)

D

L2

Spironolactone

D

L2

Disopyramide

C

L2

Flecainide

C

L3

Mexiletine

B

L2

Procainamide

C

L3

Quinidine

C

L2

Captopril

D

L3 (if used after 30 days)

Diltiazem/Diltiazem HCL

C

L3

Enalapril/Enalapril Maleate

C (1st trim.)
D (2nd, 3rd trim.)

L2

Hydralazine

C

L2

Labetalol

C

L2

Methyldopa

C

L2

Metoprolol

B

L3

Minoxidil

C

L2(topically)
L3 (orally)

Nadolol

C

L4

Nifedipine

C

L2

Oxprenolol

NR

Propranolol

C

L2

Sotalol

B

L3

Timolol

C

L2

Verapamil

C

L2

Digoxin

C

L2

Approved: (Table 6) Maternal Medication Usually Compatible With Breastfeeding*  Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.

      • Concern: (Table 4) Drugs for Which the Effect on Nursing Infants Is Unknown but May Be of Concern
      • Caution: (Table 5) Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution
      • NR: Not Reviewed. This drug has not yet been reviewed by the AAP.

** Per Medications’ and Mothers’ Milk by Thomas Hale, PhD (2004 edition).

 Lactation Risk Categories  Pregnancy Risk Categories
  • L1 (safest)
  • L2 (safer)
  • L3 (moderately safe)
  • L4 (possibly hazardous)
  • L5 (contraindicated)
  • A (controlled studies show no risk)
  • B (no evidence of risk in humans)
  • C (risk cannot be ruled out)
  • D (positive evidence of risk)
  • X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
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